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プロジェクト
○本研究会会員によるプロジェクトを募集します(締切はありません)。
○光学活性に関する研究であれば、分野は問いません。
○研究の推進、業績発信(アピール)に活用ください。

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研究紹介
 【共同研究プロジェクト】
注)共同研究を推進するため、複数の研究室の教員で構成されるプロジェクトを「共同研究プロジェクト」として紹介します。
○天然にあるキラル化合物からの包接結晶創製と光学分割への応用
  工学研究科 赤染 元浩、松本 祥治、共用機器センター 桝 飛雄真

○新規3次元ケミカルスペースの構築によるWntシグナリング制御
  理学研究科 荒井 孝義、薬学研究院 荒井 緑、石橋 正己

○キラル金属アルコキシド触媒の創製と有用物質合成反応への応用
  理学研究科 柳澤 章、吉田 和弘


○光学活性イミダゾリジン-金属錯体触媒の高次機能の解明
  理学研究科 荒井 孝義、共用機器センター 桝 飛雄真
  立教大学理学部 山中 正浩

 

【研究プロジェクト】
脱芳香化を基盤とする新しい有機合成法の開発
  薬学研究院 根本 哲宏、濱田 康正

○超分子集合体におけるキラリティーの動的制御
  工学研究科 矢貝 史樹、唐津 孝

○新開発ハイスループットdiacylglycerol kinase活性測定系を用いた多様な難治性疾患に対する新規治療薬の開発
  理学研究科 坂根 郁夫、堺 弘道

○ジャドマイシン類の合成研究
  薬学研究院 石川 勉

○ジヒドロベンゾフラン骨格を有する軸不斉ビスホスフィンを用いた遷移金属錯体による触媒的不斉反応
  工学研究科 三野 孝、坂本 昌巳

○ヒドロカルバゾール類の触媒的不斉合成法の確立と生理活性物質の全合成研究
  薬学研究院 原田 真至、西田 篤司


○アデノシンA2a受容体の新規薬剤結合部位の同定とリード化合物の創出
  理学研究科 村田 武士、水谷 健二
写真 写真 写真 写真
荒井(孝)-荒井(緑)-石橋 柳澤-吉田  三野-坂本 荒井(孝)-桝-山中
写真 写真 写真 写真
赤染-松本-桝 矢貝-唐津 坂根-堺 根本-濱田
写真
村田-水谷

【最近の研究活動から】 *運営委員、プロジェクト推進者に下線を引いています。

2016

1.        Arai, M. A.; Kofuji, Y.; Tanaka, Y.; Yanase, N.; Yamaku, K.; Fuentes, R. G.; Karmakar, U. K.; Ishibashi, M. Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities Org. Biomol. Chem. in press.

2.        Ahmed, F.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ishibashi, M. Constituents from Entada scandens with TRAIL-resistance overcoming activity. Nat. Prod. Commun. in press.

3.        Abdelfattah, M. S.; Ishikawa, N.; Karmakar, U. K.; Yamaku, K.; Ishibashi, M. New phenazine analogues from Streptomyces sp. IFM 11694 with Wnt signaling inhibitory and TRAIL resistance-overcoming activities J. Antibiot. in press.

4.        Kume, A.; Kawase, K.; Komenoi, S.; Usuki, T.; Takeshita, E.; Sakai, H.; Sakane, F. The pleckstrin homology domain of diacylglycerol kinase η strongly and selectively binds to phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. in press.

5.        Liu, K.; Kunii, N.; Sakuma, M.; Yamaki, A.; Mizuno, S.; Sato, M.; Sakai, H.; Kado, S.; Kumagai, K.; Kojima, H.; Okabe, T.; Nagano, T.; Shirai, Y.; Sakane, F. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J. Lipid Res. 2016, 57, 368–379.

6.        Nakajima, M.; Arai, S.; Nishida, A. Total Syntheses of (+)-Grandilodine C and (+)-Lapidilectine B and Determination of their Absolute Stereochemistry. Angew. Chem. Int. Ed. 2016, 55, 3473-3476.

7.        Yagai, S.; Seki, T.; Aonuma, H.; Kawaguchi, K.; Karatsu, T.; Okura, T.; Sakon, A.; Uekusa, H.; Ito, H. Mechanochromic Luminescence Based on Crystal-to-Crystal Transformation Mediated by a Transient Amorphous State. Chem. Mater., 2016, 28, 234-241.

8.        Arai, T.; Tokumitsu, C.; Miyazaki, T.; Kuwano, S.; Awata A. Catalytic Asymmetric [3+2]-Cycloaddition for Stereodivergent Synthesis of Chiral Indolyl-pyrrolidines. Org. Biomol. Chem. 2016, 14, 1831-1839.

2015

1.       Nemoto, T.; Yamaguchi, M.; Kakugawa, K.; Harada, S.; Hamada, Y. Enantioselective Total Synthesis of (+)-Gephyrotoxin 287C. Adv. Synth. Catal. 2015, 357, 2547–2555.

2.       Nakano, S.; Inoue, N.; Hamada, Y.; Nemoto, T. Pd-Catalyzed Cascade Cyclization by Intramolecular Heck Insertion of an Allene–Allylic Aminaiton Sequence: Application to the Synthesis of 3,4-Fused Tricyclic Indoles. Org. Lett. 2015, 17, 2622–2625.

3.       Nemoto, T.; Hamada, Y. Synthesis of Spirocyclic or Fused Cyclic Compounds Using Transition Metal-Catalyzed Dearomatization of Phenols. J. Synth. Org. Chem. Jpn. 2015, 73, 977–986.

4.       Harada, S.; Kono, M.; Nozaki, T.; Menjo, Y.; Nemoto, T.; Hamada, Y. General Approach to Nitrogen-Bridged Bicyclic Frameworks by Rh-Catalyzed Formal Carbenoid Insertion into an Amide C–N Bond. J. Org. Chem. 2015, 80, 10317–10333.

5.       Harada, S.; Moriguchi, E.; Kono, M.; Hamada, Y.; Nemoto, T. Diastereoselective Synthesis of Quinolizidin-4-one and Indolizidin-3-one Derivatives with a Spirocyclic Motif via Cascade Cyclization Using a Gold(I) / Brønsted Acid Relay Catalysis. Tetrahedron Lett. 2015, 56, 6266–6268.

6.       Nemoto, T.; Tsuruda, K.; Yoshida, M.; Kono, M.; Hamada, Y. Diastereoselective Synthesis of Tri-substituted Cyclopropanes Using a Pd-Catalyzed Intramoelcular Allylic Alkylation of alpha-Aryl Esters. Synthesis 2015, 47, 3914–3924.

7.       Watanabe, K.; Mino, T.; Hatta, C.; Ito, S.; Sakamoto, M. Hydrazone-palladium catalyzed annulation of 1-allyl-2-bromobenzene derivatives with internal alkynes. Org. Biomol. Chem., 2015, 13, 11645-11650.

8.       Takeda, T.; Harada, S.; Nishida, A. Catalytic Asymmetric Nazarov Cyclization of Heteroaryl Vinyl Ketones through a Crystallographically Defined Chiral Dinuclear Nickel Complex. Org. Lett. 2015, 17, 5184–5187.

9.       Yamauchi, M.; Ohba, T.; Karatsu, T.; Yagai, S. Photoreactive helical nanoaggregates exhibiting morphology transition on thermal reconstruction. Nat. Commun. 2015, 6, Article number: 8936 (OPEN ACCESS).

10.    Arai, M. A.; Ishikawa, N.; Tanaka, M.; Uemura, K.; Sugimitsu, N.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. Hes1 dimer inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells Chem. Sci. in press.

11.   Karmakar, U. K.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Bioassay-guided isolation of compounds with TRAIL-resistance overcoming activity from Datura stramonium. Nat. Prod. Commun. in press

12.    Yoshida, K.; Kamimura, T.; Kuwabara, H.; Yanagisawa, A. Chiral Bicyclic NHC/Ir Complexes for Catalytic Asymmetric Transfer Hydrogenation of Ketones, Chem. Commun. 2015, 51, 15442-15445.

13.    Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits Wnt signaling pathway by decreasing β-catenin mRNA expression. Bioorg. Med. Chem. Lett. 2015, 25, 3937-3940.

14.    Yixizhuoma; Tsukahara, K.; Toume, K.; Ishikawa, N.; Abdelfattah, M. S.; Ishibashi, M. Novel cytotoxic isobenzofuran derivatives from Streptomyces sp. IFM 11490. Tetrahedron Lett. in press.

15.    Sato, T.; Miyazaki, T.; Arai, T. Synthesis of Highly Functionalized Chiral Benzopyrano[3,4-c]pyrrolidines Bearing Five Contiguous Stereogenic Centers J. Org. Chem. 2015, 80, 10346-10352.

16.    Moriyama, K.; Nishinohara, C.; Sugiue, T.; Togo, H. Oxidative Oxygen-Nucleophilic Bromo-Cyclization of Alkenyl Carbonyl Compounds Without Organic Wastes Using Alkali Metal Reagents in Green Solvent,  RSC Advances, 2015, Accepted Manuscripts.

17.    Mino, T.; Miura, K.; Taguchi, H.; Watanabe, K.; Sakamoto, M. BICMAP-rhodium(I)-catalyzed asymmetric 1,4-addition of arylboronic acids to coumarins. Tetrahedron: Asymmetry, 2015, 26, 1065-1068.

18.    Arai, T.; Watanabe, O.; Yabe, S.; Yamanaka, M. Catalytic asymmetric iodocyclization of N-Ts alkenamides using aminoiminophenoxy copper carboxylate: a concise synthesis of chiral 8-oxa-6-azabicyclo[3.2.1]octanes Angew. Chem. Int. Ed. 2015, 54, 12767-12771.

19.    Morikawa, T.; Harada, S.; Nishida, A. "Chiral Holmium Complex-Catalyzed Synthesis of Hydrocarbazole from Siloxyvinylindole and Its Application to the Enantioselective Total Synthesis of ()-Minovincine" J. Org. Chem. 2015, 80, 8859-8867.

20.    Moriyama, K.; Sugiue, T.; Nishinohara, C.; Togo, H. Divergent Synthesis of a,g-Disubstituted g-Butyrolactones through Diastereoselective Bromo-lactonization Using Alkali Metal Bromides. J. Org. Chem. 2015, 80, ASAP.

21.    Yanagisawa, A.; Kushihara, N.; Sugita, T.; Horiguchi, M.; Ida, K.; Yoshida, K. Catalytic Enantioselective Synthesis of Chiral 3-Amino-2-oxindoles by a Mannich Approach. Synlett, accepted for publication.

22.    Arai, T.; Kojima, T.; Watanabe, O.; Itoh, T.; Kanoh, H. Recyclable poly-Zn3(OAc)4-3,3'-bis(aminoimino)binaphthoxide catalyst for asymmetric iodolactonization. ChemCatChem, 2015, 7, 3234-3238.

23.    Moriyama, K.; Sugiue, T.; Saito, Y.; Katsuta, S.; Togo, H. 2,6-Bis(amido)benzoic Acid with Internal Hydrogen Bond as Brønsted Acid Catalyst for Friedel–Crafts Reaction of Indoles. Advanced Synthesis & Catalysis, 2015, 357, 2143-2149.

24.    Yoneyama, T.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Hedgehog inhibitors from Withania somnifera. Bioorg. Med. Chem. Lett. 2015, 25, 3541-3544.

25.    Arai, M. A.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens. Bioorg. Med. Chem. 2015, 23, 4150-4154.

26.    Karmakar, U. K.; Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium. Bioorg. Med. Chem. 2015, 23, 4746-4754.

27.    Arai, M. A.; Akamine, R.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Hedgehog/GLI- mediated transcriptional activity inhibitors from Crinum asiaticum. J. Nat. Med. 2015, 69, 538-542.

28.    Shono, T.; Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Boehmenan, a lignan, isolated from Hibiscus ficulneus showed Wnt signal inhibitory activity. Bioorg. Med. Chem. Lett. 2015, 25, 2735-2738.

29.    Fuentes, R. G.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Phenolic compounds from the bark of Oroxylum indicum identified as Ngn2 promoter activators. J. Nat. Med. 2015, 78, 864-872.

30.    Arai, T.; Moribatake, T.; Masu, H. Chiral bis(imidazolidine)-derived NCN pincer Rh complex for catalytic asymmetric Mannich reaction of malononitrile with N-Boc imines. Chem. Eur. J. 2015, 21, 10671-10675..

31.    Ogasawara, M.; Wada, S.; Isshiki, E.; Kamimura, T.; Yanagisawa, A.; Takahashi, T.; Yoshida, K. Enantioselective Synthesis of Planar-Chiral Ferrocene-Fused 4-Pyridones and Their Application in Construction of Pyridine-Based Organocatalyst Library. Org. Lett. 2015, 17, 2286-2289.

32.    Ohishi, K.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Mizoguchi, T.; Itoh, M.; Ishibashi, M. 9-Hydorxycanthin-6-one, a β-carboline alkaloid from Eurycoma longifolia, is the first Wnt signal inhibitor through activation of GSK3β without depending on CK1α. J. Nat. Prod. in press

33.    Fuentes, R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Scopadulciol, isolated from Scoparia dulcis, induces β-catenin degradation and overcomes tumor necrosis factor-related apoptosis ligand resistance in AGS human gastric adenocarcinoma cells J. Nat. Prod. 2015, 78, 864-872.

34.    Fuentes, R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa Phytochem. Lett. 2015, 11, 280-285.

35.    Arai, M. A.; Koryudzu, K.; Ishibashi, M. Inubosin A, B, and C are new acridine alkaloids isolated from Streptomyces sp. IFM 11440 that show Ngn2 promoter activity J. Nat. Prod. 2015, 78, 311-314.

36.    Arai, T.; Tsuchiya, K.; Matsumura, E. PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines. Org. Lett. 2015, 2416-2419.

37.    Komenoi, S.; Takemura, F.; Sakai, H.; Sakane, F. Diacylglycerol kinases η1 is a high affinity isozyme for diacylglycerol. FEBS Lett., 2015, 589, 1272-1277.

38.    Arai, S.; Hori, H.; Amako, Y.; Nishida, A. A New Protocol for Nickel-catalysed Regio- and Stereoselective Hydrocyanation of Allenes. Chem. Commun. 2015, 51, 7493-7496.

39.    Nakajima, M.; Arai, S.; Nishida, A. Asymmetric Total Synthesis of (-)-Lundurine B and Determination of Its Absolute Stereochemistry. Chem. Asian J. 2015, 10, 1065-1070.

40.    Shionoya, T., Usuki, T., Komenoi, S., Isozaki, T., Sakai, H. and Sakane, F. Distinct expression and localization of type II diacylglycerol kinase isozymes δ, η and κ in mouse reproductive organs. BMC Dev. Biol., 2015, 15, 6.

41.    Arai, T.; Ogawa, H.; Awata, A.; Sato, M.; Watabe, M.; Yamanaka, M. PyBidine-Cu(OTf)2-catalyzed asymmetric [3+2] cycloaddition using imino esters: Harmony of Cu-Lewis acid and imidazolidine-NH hydrogen-bonding in concerto catalysis. Angew. Chem. Int. Ed. 2015, 54, 1595-1599.

42.    Harada, S.; Ishii, H.; Shirasaki, D.; Nishida, A. Catalytic and Enantioselective Synthesis of a Key Intermediate of the MCHr1 Antagonist AMG 076 HeteroCycles 2015, 90, 967-977.

43.    Arai, T.; Joko, A. Sato K. Design of a Chiral Secondary Amine Ligand for Cu-catalyzed anti-Selective Henry Reaction. Synlett, 2015, 26, 209-214.

44.    Usuki, T.; Sakai, H.; Shionoya, T.; Sato, N.; Sakane, F. Expression and localization of type II diacylglycerol kinase isozymes δ and η in developing mouse brain. J. Histochem. Cytochem., 2015, 63, 57-68.

2014

1.       Yoshida, K.; Morikawa, T.; Yokozuka, N.; Harada, S.; Nishida. A. Stereoselective synthesis of chiral hydrocarbazoles via the catalytic Diels–Alder reaction of siloxyvinylindole and cyclic Z-olefin. Tetrahedron Lett. 2014, 55, 6907-6910.

2.       Arai, M. A.; Uemura, K.; Hamahiga, N.; Ishikawa, N.; Koyano, T.; Kowithayakorn, T.; Kaddar, T.; Carreau, M.; Ishibashi, M. Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa. Med. Chem. Commun. in press.

3.       Tsukahara, K.; Toume, K.; Ito, H.; Ishikawa, N.; Ishibashi, M. Isolation of β-indomycinone guided by cytotoxicity tests from Streptomyces sp. IFM11607 and revision of its double bond geometry. Nat. Prod. Commun. 2014, 9, 1327-1328.

4.       Tahmina, H.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Isolation of alkamides with death receptor-enhancing activities from Piper chaba. Heterocycles in press.

5.       Yokosaska, T.; Nemoto, T.; Nakayama, H.; Shiga, N.; Hamada Y. Synthesis of Nitrogen-Containing Fused-Polycyclic Compounds from Tyramine Derivatives Using Phenol Dearomatization and Cascade Cyclization. Chem. Commun. 2014, 50, 12775–12778.

6.       Suzuki, Y.; Nemoto, T.; Nakano, S.; Zhao, Z.; Yoshimatsu, Y.; Hamada Y. Synthesis of 4,5-Fused Tricyclic Quinolines via an Acid-Promoted Intramolecular Friedel–Crafts Allenylation of Aniline Derivatives. Tetrahedron Lett. 2014, 55, 6726–6728.

7.       Yagai, S. Supramolecularly Engineered Functional π-Assemblies based on Complementary Hydrogen Bonding Interactions. Bull. Chem. Soc. Jpn., 2014, 88, 28-58 (Award Account: Open Access).

8.       Yagai, S: Suzuki, M; Lin, X.; Gushiken, M.; Noguchi, T.; Karatsu, T.; Kitamura, A.; Saeki, A.; Seki, S.; Kikkawa, Y.; Tani, Y.; Nakayama, K. Supramolecular Engineering of Oligothiophene Nanorods without Insulators: Hierarchical Association of Rosettes and Photovoltaic Properties. Chem, Eur. J. 2014, 20, 16128-16137 (Selected as back cover).

9.       Watanabe, K.; Mino, T.; Abe, T.; Kogure, T.; Sakamoto, M. Hydrazone-palladium-catalyzed allylic arylation of cinnamyloxyphenylboronic acid pinacol esters, J. Org. Chem., 2014, 79, 6695-6702.

10.    Mino, T.; Yoshizawa, E.; Watanabe, K.; Abe, T.; Hirai, K.; Sakamoto, M., Palladium-catalyzed decarboxylative coupling of benzoic acid derivatives using hydrazone ligands, Tetrahedron Lett., 2014, 55, 3184-3188.

11.    Abe, T.; Mino, T.; Watanabe, K.; Yagishita, F.; Sakamoto, M., Suzuki-Miyaura Coupling of Aryl Sulfonates with Arylboronic Acids Using a Morpholine-Pd(OAc)2 Catalyst System, Eur. J. Org. Chem., 2014, 3909-3916.

12.    Yagishita, F.; Baba, N.; Ueda, Y.; Katabira,S.; Kasashima,Y.; Mino, T.; Sakamoto, M., Diastereoselective Photodimerization Reactions of Chromone-2-carboxamides to Construct a C2-Chiral Scaffold, Org. Biomol. Chem., 2014, DOI: 10.1039/C4OB01827C.

13.    Yagishita, F.; Takagishi, N.; Ishikawa, H.; Kasashima, Y.; Mino, T.; Sakamoto, M., Deracemization of Quinolonecarboxamides by Dynamic Crystalline Salt Formation and Asymmetric Photoreaction Using the Frozen Chirality, Eur. J. Org. Chem., 2014, DOI:ejoc.201403056.

14.    Takahashi, M.; Murata, Y.; Yagishita, F.; Sakamoto, M.; Sengoku, T.; Yoda, H., Catalytic Enantioselective Amide Allylation of Isatins and Its Application to the Synthesis of 2-Oxindole Derivatives Spiro-Fused to a-Methylene-g-Butyrolactone Functionality, Chem. Eur. J. 2014, 20, 11091-11100.

15.    Takahashi, M.; Murata, Y.; Ishida, M.; Yagishita,F.; Sakamoto, M.; Sengoku, T.; Yoda, H., Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones, Org. Biomol. Chem., 2014, 12, 7686-7689.

16.    Sengoku, T.; Suzuki, K.; Nakayama, K.; Yagishita, F.; Sakamoto, M.; Takahashi, M.; Yoda, H., Novel chiral tetramic acid-derived diols: organocatalytic facile synthesis and unique structural properties, RSC Adv., 2014, 4, 30775-30779.

17.    Sakai, H., Kado, S., Taketomi, A. and Sakane, F. Diacylglycerol kinase δphosphorylates phosphatidylcholine-specific phospholipase C-dependent, palmitic acid-containing diacylglycerol species in response to high glucose levels. J. Biol. Chem. 2014, 289, 26607-26617.

18.    Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Mizoguchi, T.; Itoh, M.; Ishibashi, M. "Ricinine: a pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α" Bioorg. Med. Chem. 2014, in press

19.    Hamada, Y.: Diastereo- and enantioselective anti-selective hydrogenation of a-amino-b-keto ester hydrochlorides and related compounds using transition-metal-chiral-bisphosphine catalysts. Chemical Record 2014, 14, 235-250.

20.    Awata, A.; Arai, T. PyBidine/Copper Catalyst: Asymmetric exo′-Selective [3+2] Cycloaddition using Imino Ester and Electrophilic Indole. Angew. Chem. Int. Ed. 2014, 53, 10462-10465.

21.    Nemoto, T.; Matsuo, N.; Hamada Y. Gold-Catalyzed Carbocyclization of Phenols with a Terminal Alkyne via an Intramolecular ipso-Friedel–Crafts Alkenylation. Adv. Synth. Catal. 2014, 356, 2417.

22.    Nemoto, T.; Hayashi, M.; Xu, D.; Hamajima, A.; Hamada, Y. Enantioselective synthesis of (R)-sumanirole using organocatalytic asymmetric azilidination of an a,b-unsaturated aldehyde. Tetrahedron: Asymmetry 2014, 25, 1133-1137.

23.    Yagai, S.; Okamura, S.; Nakano, Y.; Yamauchi, M.;Kishikawa, K.; Karatsu, T.; Kitamura, A.; Ueno, A.; Kuzuhara, D.; Yamada, H.; Seki, T.; Ito, H. Design Amphiphilic Dipolar Systems for Stimuli-Responsive Luminescent Materials Using Metastable States. Nat. Comm. 2014, 5, 4013.

24.    Arai, T.; Sugiyama, N.; Masu, H.; Kado, S.; Yabe, S.; Yamanaka, M. Trinuclear Zn3(OAc)4-3,3’-bis(aminoimino)binaphthoxide Complex for Highly Efficient Catalytic Asymmetric Iodolactonization. Chem. Comm. 2014, 42, 8287-8290.

25.    Arai, S.; Nakajima, M.; Nishida, A. A Concise and Versatile Synthesis of Alkaloids from Kopsia tenuis: Total Synthesis of (±)–Lundurine A and B. Angew. Chem. Int. Ed. 2014, 53, 5669-5572.

26.    Toume, K.; Tsukahara, K.; Ito, H.; Arai, M. A.; Ishibashi, M. Chromomycins A2 and A3 from marine actinomycete with TRAIL resistance-overcoming activity and Wnt signal inhibitory activity" Mar. Drugs, in press

27.    Yanagisawa, A.; Miyake, R.; Yoshida, K. Asymmetric Aldol Reaction Catalyzed by a Chiral Phosphine-Silver Complex, Eur. J. Org. Chem. 2014, 4248-4253.

28.    Yokosaka, T.; Shiga, N.; Nemoto, T.; Hamada, Y. Construction of Divergent Fused-Heterocycles via an Acid-Promoted Intramolecular ipso-Friedel–Crafts Alkylation of Phenol Derivatives. J. Org. Chem. 2014, 79, 3866–3875.

29.    Arai, T.; Matsumura, E.; Masu, H. Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles. Org. Lett. 2014, 16, 2768-8522.

30.    Yokosaka, T.; Kanehira, T.; Nakayama, H.; Nemoto, T.; Hamada, Y. Synthesis of fused-tricyclic indole derivatives through an acid promoted skeletal rearrangement. Tetrahedron 2014, 70, 2151–2160.

31.    Nakano, S. Kakugawa, K.; Nemoto, T.; Hamada, Y. Scandium-Catalyzed Cascade Cyclization to Produce Cyclobutane-Fused  Tetrahydroquinoline, Chromane, Thiochromane, and  Tetrahydronaphthalene Derivatives. Adv. Synth. Catal. 2014, 356, 2088–2096.

32.    Arai, T.; Matsumura, E. Switching Enantioface Selection in the Asymmetric Nitro-Mannich Reaction Using Single Chiral Bis(imidazolidine)pyridine-metal Catalysts. Synlett 2014, 25, 1776-1780.

33.    Park, H.-Y.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Calotropin: a cardenolide from Calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1α in colon cancer cells" ChemBioChem 2014, 15, 872-878.

34.    Sakiyama, S.; Usuki, T.; Sakai, H.; Sakane, F. Regulation of diacylglycerol kinase δ expression in C2C12 skeletal muscle cells by free fatty acids. Lipids, 2014, 49, 633-640.

35.    Yamamoto, T.; Sakai, H.; Sakane, F. EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains. FEBS Open Bio. 2014, 4, 387-392.

36.    Kano, T.; Kouzuki, T.; Mizuno, S.; Ueda, S.; Yamanoue, M.; Sakane, F.; Saito, N.; Shirai, Y. Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ. Biochem. Biophys. Res. Commun., 2014, 447, 89-94.

37.    Arai, T.; Yamamoto, Y. Diversity-Oriented Asymmetric Catalysis (DOAC): Stereochemically Divergent Synthesis of Thiochromanes Using an Imidazoline-Aminophenol-Nickel Catalyzed Michael/Henry Reaction. Org. Lett. 2014, 16, 1700-1703.

38.    Hoshi, M.; Kaneko, O.; Nakajima, M.; Arai, S.; Nishida, A. Total Synthesis of (±)–Lundurine B. Hoshi, M.; Kaneko, O. Org. Lett. 2014, 16, 768-771.

39.    Takeshita, E., Kume, I., Maeda, Y., Sakai, H. Sakane, F.  Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. Biochem. Biophys. Res. Commun., 2014, 444, 617-621.   

40.    Hori, H.; Arai, S.; Nishida, A. Asian. A 2-Benzothiazolylphenyl Group Accelerates the Intramolecular [2+2] Cycloaddition of Allene–ynes. Asian J. Org. Chem. 2014, 3, 41-43.

41.    Yagai, S.; Iwai, K.; Yamauchi, M.; Karatsu, T.; Kitamura, K.; Uemura, S.; Morimoto, M.; Wang, H.; Würthner, F. Photocontrol over Self-Assembled Nanostructures of π−π Stacked Dyes Supported by the Parallel Conformer of Diarylethene. Angew. Chem. Int. Ed. 2014, 53, 2602-2606.

42.    Lin, X.; Hirono, M.; Kurata, H.; Seki, T.; Maruya, Y.; Nakayama, K.; Yagai, S. A Perylene Bisimide Organogelator for Chlorinated Solvents Asian J. Org. Chem. 2014, 3, 128-132.

43.    Yanagisawa, A.; Miyake, R.; Yoshida, K. Asymmetric α-Amination Reaction of Alkenyl Trifluoroacetates  Catalyzed by Chiral Phosphine-Silver Complex, A. Org. Biomol. Chem. 2014, 12, 1935-1941.

44.    Awata, A.; Wasai, M.; Masu, H.; Kado, S.; Arai, T. Imidazoline-aminophenol (IAP)-nickel complex: Structure and catalytic activity in enantioselective 1,4-addition of 3'-indolyl-3-oxindoles to nitroethylene. Chem. Eur. J. 2014, 20, 2470-2477.

45.    Sato, T.; Arai, T. Chiral Bis(oxazolidine)pyridine–Cu-Catalyzed Enantioselective Friedel–Crafts Alkylation of Indoles with Nitroalkenes. Synlett, 2014, 25, 349-354.

46.    Oyama, S.; Fujino, H.; Yamazaki, R.; Okura, I.; Regan, J. W.; Awata, A.; Arai, T.; Murayama, T. Novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells, Archives of Biochemistry and Biophysics, 2014, 541, 21-29.

47.    Yanagisawa, A.; Lin, Y.; Miyake, R.; Yoshida, K. Catalytic Enantioselective Mannich-Type Reaction via a Chiral Silver Enolate, Org. Lett., 2014, 16, 86-89.

2013

1.      Hino, T.; Iwata, S.; Murata, T., Generation of functional antibodies for mammalian membrane protein crystallography. Current opinion in structural biology 2013, 23, 563-568.

2.      Arai, S.; Saijo, S.; Suzuki, K.; Mizutani, K.; Kakinuma, Y.; Ishizuka-Katsura, Y.; Ohsawa, N.; Terada, T.; Shirouzu, M.; Yokoyama, S.; Iwata, S.; Yamato, I.; Murata, T., Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures. Nature 2013, 493, 703-707.

3.      Arai, M. A.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Physalin H from Solanum nigrum as Hh signaling inhibitor blocks GLI1-DNA complex formation Beil. J. Org. Chem.in press.

4.      Toume, K.; Kamiya, K.; Arai, M. A.; Mori, N.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Xylogranin B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatum Org. Lett. in press DOI:10.1016/ol4029995

5.      Yagishita, F.; Okamoto, K.; Kamataki, N.; Kanno, S.; Mino, T.; Kasashima, Y.; Sakamoto, M. Chiral Symmetry Breaking of Axially Chiral Nicotinamide by Crystallization from the Melt Chem. Lett., 2013, in press. (doi:10.1246/cl.130796)

6.      Uehata, K.; Kimura, N.; Hasegawa, K.; Arai, S.; Nishida, M.; Hosoe, T.; Kawai, K.; Nishida, A. Total Synthesis of Schizocommunin and Revision of Its Structure. J. Nat. Pro. 2013, 76, 2034-2039.

7.      Kawaguchi, K.; Seki, T.; Karatsu, T.; Kitamura, A.; Ito, H.; Yagai S. Cholesterol-Aided Construction of Distinct Self-Organized Materials from Luminescent Gold(I)-Isocyanide Complex Exhibiting Mechanochromic Luminescence. Chem. Commun. 2013, 49, 11391-11393.

8.      Lin,X.; Tani,Y.; Kanda,R.; Nakayama, K.; Yagai S. Indolocarbazoles end-capped with diketopyrrolopyrroles: impact of regioisomerism on the solid-state property and the performance of solution-processed bulk heterojunction solar cells. J. Mater. Chem. A, 2013, 1, 14686-14691.

9.      Fuentes, R. G.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. Constitutents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activity. Heterocycles in press.

10.    Minakawa, T.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. Prenylflavonoids isolated from Artocarpus  champeden with TRAIL-resistance overcoming activity. Phytochemistry in press.

11.    Park, H.-Y.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn,  T.; Ishibashi, M. b-sitosterol and flavonoids isolated from Bauhinia malabarica found in a screening program for Wnt signal inhibitory activity. J. Nat. Med. in press.

12.    Yanagisawa, A.; Sugita, T.; Yoshida, K. Enantioselective Protonation of Alkenyl Trifluoroacetates Catalyzed by Chiral Tin Methoxide Chem. Eur. J. 2013, 19, 16200-16203.

13.    Yagishita, F.; Kamataki, K.; Okamoto, K.; Kanno, S.; Mino, T.; Masu, H.; Sakamoto, M. Deracemization of Axially Chiral Nicotinamides by Dynamic Salt Formation with Enantiopure Dibenzoyltartaric Acid (DBTA) Molecules 2013, 18, 14430-14447.

14.    Amako, Y.; Hori H.; Arai, S.; Nishida, A. Regioselective Hydronickelation of Allenes and Its Application to the Hydrocyanative Carbocyclization Reaction of Allene-ynes. J. Org. Chem. 2013, 78, 10763-10775.

15.    Arai, S.; Amako, Y.; Yang, X.; Nishida, A. Hydrocyanative Cyclization and Three-component Cross-coupling Reaction between Allenes and Alkynes under Nickel Catalysis. Angew. Chem. Int. Ed. 2013, 52, 8147-8150.

16.    Arai, T.; Ogino, Y.; Sato, T. Development of a Tailor-made Bis(oxazolidine)pyridine-metal Catalyst for the [3+2] Cycloaddition of Azomethine Imines with Propiolates. Chem. Commun. 2013, 49, 7776-7778. – featured in “inside back cover

17.    Ishiuchi, K.; Nakazawa, T.; Yagishita, F.; Mino, T.; Noguchi, H.; Hotta, K.; Watanabe, K. Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis. J. Am. Chem. Soc., 2013, 135, 7371-7377.

18.    Yagai, S.; Ishiwatari, K.; Lin, X.; Karatsu, T.; Kitamura, A.; Uemura S. Rational Design of Photoresponsive Supramolecular Assemblies Based on Diarylethene. Chem. Eur. J. 2013, 19, 6971–6975.

19.    Lin, X.; Hirono, M.; Seki, T.; Kurata, H.; Karatsu, T.; Kitamura, A.; Kuzuhara, D.; Yamada, H.; Ohba, T.; Saeki, A.; Seki, S.; Yagai S. Covalent Modular Approach for Dimension-Controlled Self-Organization of Perylene Bisimide Dyes. Chem. Eur. J. 2013, 19, 6561-6565.

20.    Harada, S.; Morikawa, T.; Nishida, A. Chiral Holmium Complex-Catalyzed Diels-Alder Reaction of Silyloxyvinylindoles: Stereoselective Synthesis of Hydrocarbazoles Org. Lett. 2013, 15, 5314-5317.

21.    Yamauchi, M.; Kubota, S.; Karatsu, T.; Kitamura,  A.; Ajayaghosh, A.; Yagai S. Guided supramolecular polymerization of oligo(p-phenylenevinylene) functionalized bismelamines. Chem. Commun 2013, 49, 4941-4943.

22.    Hachiya, S.; Kasashima, K.; Yagishita, F.; Mino, T.; Masu, H.; Sakamoto, M. Asymmetric transformation by dynamic crystallization of achiral succinimides. Chem. Commun., 201349, 4776-4778.

23.    Igarashi, T.; Arai, S.; Nishida, A. Anti-carbocyanative Cyclization of Enynes under Nickel Catalysis. J. Org. Chem. 2013, 78, 4366-4372.

24.    Kaneko, Y. K.; Kobayashi, Y.; Motoki, K.; Nakata, K.; Miyagawa, S.; Yamamoto, M.; Hayashi, D.; Shirai, Y.; Sakane, F.; Ishikawa, T. Depression of type I diacylglycerol kinases in pancreatic β-cells from male mice results in impaired insulin secretion. Endocrinology, 2013, 154, 4089–4098.

25.    Yokosaka, T.; Nakayama, H.; Nemoto, T.; Hamada, Y. Acid-promoted Cascade Cyclization to Produce Fused-polycyclic Indole Derivatives. Org. Lett. 2013, 15, 2978–2981.

26.    Yang, X.;  Arai, S.; Nishida, A. Catalytic Cyanation of Carbon–Carbon Triple Bonds Through a Three-Component Cross-coupling Reaction under Nickel Catalysis. Adv. Synth. Catal. 2013, 355, 2974-2981.

27.    Nemoto, T.; Nozaki, T.; Yoshida, M.; Hamada, Y. Palladium-Catalyzed Intramolecular ipso-Friedel-Crafts Allylic Alkylation of Phenols via Arylative Activation of Allenes. Adv. Synth. Catal. 2013, 355, 2693-2700.

28.    Arai, M. A.; Koryudzu, K.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Naturally Occurring Ngn2 Promoter Activators from Butea superba" Mol. BioSyst., 2013, 9, 2489-2497.

29.    Arai, T.; Y. Yamamoto; Awata, A.; Kamiya, K.; Ishibashi, M.; Arai, M. A. Catalytic Asymmetric Synthesis of Mixed 3,3′-Bisindoles and Their Evaluation as Wnt Signaling Inhibitors Angew. Chem. Int. Ed. 2013, 52, 2486-2490. - selected in Hot Paper

30.    Nemoto, T.; Zhao, Z.; Yokosaka, T.; Suzuki, Y.; Wu, R.; Hamada, Y. Pd-Catalyzed Intramolecular ipso-Friedel-Crafts Alkylation of Phenols and Indoles: Rearomatization-Assisted Oxidative Addition. Angew. Chem. Int. Ed. 2013, 52, 2217-2220.

31.    Arai, T.; Kajikawa, S.; Matsumura, E. The Role of Ni-carboxylate During Catalytic Asymmetric Iodolactonization Using PyBidine-Ni(OAc)2. Synlett, 2013, 24, 2045-2048.

32.    Arai, T.; Oka, I.; Morihata, T.; Awata, A.; H. Masu. A. Neutral, Chiral, Bis(imidazolidine)-derived NCN-type Palladium Pincer Complex Demonstrating Catalyst Activity. Chem. Eur. J. 2013, 19, 1554-1557. - Most Accessed Articles in January 2013

33.    Mino, T.; Taguchi, H.; Hashimoto, M.; Sakamoto, M. Copper-catalyzed asymmetric propargylic amination of propargylic acetates with amines using BICMAP Tetrahedron: Asymm., 201324, 1520-1523.

34.    Arai, M. A.; Fujimatsu, T.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1–DNA complex. Mol. BioSyst., 2013, 9, 1012-1018.

35.    Yamauchi, M.; Chiba, Y.; Karatsu, T.; Kitamura, A.; Yagai S. Self-Assembled Nanofibrils and Nanorings from Oligo(p-phenylenevinylene) Dimers. Chem. Lett. 2013, 42, 799-800.

36.    Seki, T.; Lin, Xu.; Yagai S. Supramolecular Engineering of Perylene Bisimide Assemblies Based on Complementary Multiple Hydrogen Bonding Interactions. Asian J. Org. Chem. 2013, 2, 708-724.

37.    Megumi, K.; Yokota, S.; Matsumoto, S.; Akazome, M. Enantioselective Inclusion of Amide Guests into a Chiral N,N-Ditrityl Amino Amide Host to Compensate the Loss of Hydrogen Bonds Broken by Installation of Trityl Groups. Tetrahedron Lett. 2013, 54, 707-710.

38.    Arai, T. Catalytic Asymmetric [3+2]-Cycloaddition Reaction for Controlling Multiple Stereogenic Centers on Pyrrolidines. J. Synth. Org. Chem, Japan. 2013, 71, 672-682.

39.    Mino, T.; Ishikawa, M.; Nishikawa, K.; Wakui, K.; Sakamoto, M. Palladium-catalyzed asymmetric allylic alkylation of indoles by C–N bond axially chiral phosphine ligands. Tetrahedron: Asymm., 2013, 24, 499-504.

40.    Suzuki, T.; Arai, M. A.; Nakashima, M.; Uesugi, M. Merging chemistry and biology in emerging countries. Chem. Biol. 2013, 20, 461-465.

41.    Sato, M.; Liu, K.; Sasaki, S.; Kunii, N.; Sakai, H.; Mizuno, H.; Saga, H.; Sakane, F. Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method. Pharmacology 2013, 92, 99-107.

42.    Tani, Y.; Seki, T.; Lin, X.; Kurata, H.; Yagai, S.; Nakayama K. Doping Effect of CBP in Bulk-heterojunction Photovoltaic Devices Composed of P3HT and Soluble Perylene Bisimide. Mol. Cryst. Liq. Cryst. 2013, 578, 88-94.

2012

1.       Yagai, S.; Yamauchi, M.; Kobayashi, A.; Karatsu, T.; Kitamura, A.; Ohba, T.; Kikkawa, Y. Control over Hierarchy Levels in the Self-Assembly of Stackable Nanotoroids. J. Am. Chem. Soc. 2012, 134, 18205-18208.

2.       Yagishita, F.; Ishikawa, H.; Onuki, T.; Hachiya, S.; Mino, T.; Sakamoto, S. Total Spontaneous Resolution by Deracemization of Isoindolinones. Angew. Chem., Int . Ed., 2012, 51, 13023-13025.

3.       Yagai, S.; Iwai, K.; Karatsu, T.; Kitamura, A. Merocyanine-Diarylethene Multichromophore Hydrogen-Bonded Complexes, Angew. Chem. Int. Ed. 2012, 51, 9679-9683.

4.       Yagai, S.; Usui, M.; Seki, T.; Murayama, H.; Kikkawa, Y.; Uemura, S.; Karatsu, T.; Kitamura, A.; Asano, A.; Seki, S. Supramolecularly Engineered Perylene Bisimides Assemblies Exhibiting Thermal Transition from Columnar to Multilamellar Structures, J. Am. Chem. Soc. 2012, 134, 7983-7994.

5.       Yagai, S.; Goto, Y.; Lin, X.; Karatsu, T.; Kitamura, A.; Kuzuhara, D.; Yamada, H.; Kikkawa, Y.; Saeki, A.; Seki, S. Self-Organization of Hydrogen-Bonding Naphthalene Chromophores into J-type Nanoring and H-type Nanorod: Impact of Regioisomerism, Angew. Chem. Int. Ed. 2012, 51, 6643-6647.

6.       Megumi, K.; Binti Mohd Arif, F. N.; Matsumoto, S.; Akazome, M. Design and Evaluation of Salts between N-Trityl Amino Acid and tert-Butylamine as Inclusion Crystals of Alcohols. Cryst. Growth Des. 2012, 12, 5680-5685.

7.       Yokosaka, T.; Nemoto, T.; Hamada, Y. An Acid-Promoted Novel Skeletal Rearrangement Initiated by Intramolecular ipso-Friedel-Crafts-Type Addition to 3-Alkylidene Indolenium Cations. Chem. Commun. 2012, 48, 5431-5433.

8.       Palladium-Catalyzed Cyanation of Non-Activated Alkynes; Development of Cyanopalladation and Its Application to Cyclization and Cycloaddition Reactions. Arai, S.; Nishida, A. Synlett 2012, 23, 2880-2893. -invited accounts

9.       Yanagisawa, A.; Kushihara, N.; Sugita, T.; Yoshida, K. Catalytic Enantioselective Synthesis of Chiral Isatin Derivatives by an Aldol Approach. Synlett 2012, 23, 1783-1788.

10.    Mino, T.; Hashimoto, M.; Uehara, K.; Naruse, Y.; Kobayashi, S.; Sakamoto, M.; Fujita, T. Chiral dihydrobenzofuran-based diphosphine (BICMAP): Optical resolution and application to rhodium(I)-catalyzed asymmetric 1,4-addition of aryl- and alkenylboronic acids to cyclic enones. Tetrahedron Lett., 201253, 4562-4564.

11.    Yagishita, F.; Mino, T.; Fujita, T.; Sakamoto, M. Two-Step Asymmetric Reaction Using the Frozen Chirality Generated by Spontaneous Crystallization. Org. Lett., 2012, 14, 2638-2641.

12.    Yanagisawa, A.; Fujinami, T.; Oyokawa, Y.; Sugita, T.; Yoshida, K. Catalytic Enantioselective N-Nitroso Aldol Reaction of g,d-Unsaturated d-Lactones. Org. Lett. 2012, 14, 2434-2437.

13.    Suzuki, Y.; Nemoto, T.; Kakugawa, K.; Hamajima, A.; Hamada, Y. Asymmetric Synthesis of Chiral 9,10-Dihydrophenanthrenes Using Pd-Catalyzed Asymmetric Intramolecular Friedel-Crafts Allylic Alkylation of Phenols. Org. Lett. 2012, 14, 2350-2353.

14.    Takeuchi, M.; Sakiyama, S.; Usuki, T.; Sakai, H.; Sakane, F. Diacylglycerol kinase d1 transiently translocates to the plasma membrane in response to high glucose stimulation. Biochim. Biophys. Acta - Mol. Cell Res. 2012, 1823, 2210–2216.

15.    Mizuno, S.; Sakai, H.; Saito, M.; Kado, S.; Sakane, F. Diacylglycerol kinase-dependent formation of phosphatidic acid molecular species during interleukin-2 activation in CTLL-2 T-lymphocytes. FEBS Open Bio 2012, 2, 267–272.

16.    Hino, T.; Arakawa, T.; Iwanari, H.; Yurugi-Kobayashi, T.; Ikeda-Suno, C.; Nakada-Nakura, Y.; Kusano-Arai, O.; Weyand, S.; Shimamura, T.; Nomura, N.; Cameron, A. D.; Kobayashi, T.; Hamakubo, T.; Iwata, S.; Murata, T., G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature 2012, 482, 237-240.

17.    Yanagisawa, A.; Izumiseki, A.; Sugita, T.; Kushihara, N.; Yoshida, K. Catalytic Asymmetric Cycloaddition Reaction of Alkenyl Trichloroacetates with Nitrones. Synlett 2012, 23, 107-112.

18.    Awata, A.; Arai, T. Catalytic Asymmetric Exo'-selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3'-oxindoles. Chem. Eur. J. 2012, 18, 8278-8282.

 
       
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荒井 孝義
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